|
KMID : 1084220190260030179
|
|
Journal of Rheumatic Diseases
2019 Volume.26 No. 3 p.179 ~ p.185
|
|
|
Nonsteroidal Anti-inflammatory Drugs-sparing Effect of Symptomatic Slow-acting Drugs for Osteoarthritis in Knee Osteoarthritis Patients
|
|
Cho Soo-Kyung
Kim Hyoung-Young
Park Ha-Rim
Choi Woo-Seok
Choi Seong-Mi
Jung Sun-Young
Jang Eun-Jin
Sung Yoon-Kyoung
|
|
|
Abstract
|
|
|
Objective: To evaluate the nonsteroidal anti-inflammatory drugs (NSAID)-sparing effect of symptomatic slow-acting drugs for osteoarthritis (SYSADOA) in knee osteoarthritis (OA) patients.
Methods: A retrospective study was conducted on a cohort of knee OA patients who visited a single academic referral hospital from 2013 to 2014. Among all patients, NSAID users in their first visit were extracted and divided into SYSADOA users and SYSADOA non-users. All patients were observed from their first visit with knee OA to their last visit, NSAID discontinuation, or the date of data collection, July 2017 (mean observational periods: 369.1 days). To evaluate the NSAID-sparing effect of SYSADOA, Cox regression analysis was performed after adjusting for confounding factors.
Results: Patients for this study (n=212) were divided into SYSADOA users (n=57) and SYSADOA non-users (n=155). The mean age (68.8 vs. 66.6 years old, p=0.31) and the number of comorbidities (p=0.73) were comparable between the two groups. The SYSADOA users showed higher Kellgren?Lawrence (KL) grade (66.7% of patients with more than KL grade 3) than SYSADOA non-users (42.6% of patients with more than KL grade 3) (p=0.02). In treatment, the frequency of intra-articular injection was higher in the SYSADOA user group than the SYSADOA non-user group (33.3% vs. 9.0%, p<0.01). In Cox regression analysis, SYSADOA use contributed to NSAID discontinuation in knee OA patients (hazard ratio 2.97, 95% confidential interval 1.42∼6.22).
Conclusion: This real-world analysis demonstrated that SYSADOA use combined with NSAIDs had a significant effect on NSAID discontinuation in patients with knee OA.
|
|
|
KEYWORD
|
|
|
Osteoarthritis, Symptomatic slow-acting drugs for osteoarthritis, Nonsteroidal anti-inflammatory drugs
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|